任璐， 王井霞， 唐四元^*

（  中南大学湘雅护理学院，长沙，410013；  ）

摘要： 骨质疏松是一种以单位体积内骨组织量减少为特点的代谢性骨病变。以往研究认为，多数骨质疏松由破骨细胞活性增强，骨质吸收增多所致。近年来随着生物学技术的不断进步，成骨细胞在骨质疏松中的作用越来越受到人们的关注。人类和小鼠遗传学的发展极大的增加了我们对于成骨细胞分化和骨形成机制的理解，此外，在对人类骨质疏松疾病和小鼠骨质疏松模型的研究中，有关成骨细胞的认知为进一步发现骨质疏松的发病机制并开发有效的治疗手段提供了可能。本篇文章主要概述了成骨细胞在骨质疏松中主要的作用及机制并探讨其相关治疗研究的进展。
关键词： 病理学与病理生理学；成骨细胞；骨质疏松；骨形成

REN Lu， WANG Jingxia， TANG Siyuan^*

（  Xiangya nusing school, Central south university, Changsha；  ）

Abstract： Osteoporosis is a systemic metabolic bone disease characterized by a reduction in bone mass and bone quality. Many researchers in the past considered that the osteoporosis is mainly due to enhanced osteoclast activity and increased bone absorption. In recent years, with the constant progress of biological technology, people pay more and more attentions to the effect of osteoblast in osteoporosis. The development of human and mouse genetics greatly improved our knowledge of the biological mechanisms of bone formation. Moreover, the identification of osteoblast in human osteoporosis and mouse models led to improve our understanding of the pathogenesis of osteoporosis and develop new treatment methods for osteoporosis. This review summarizes the research progress on effect of osteoblast in osteoporosis and related treatment research.
Keywords： pathology and pathophysiology; osteoblast; osteoporosis; bone formation

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