雷晓妮^*

（  武汉体育学院；  ）

摘要： 脂肪组织在能量稳态中起重要作用，能分泌一些细胞因子。这些细胞因子的表达或活性的改变对肥胖和胰岛素抵抗等病理状态有着重要作用。然而骨骼肌在代谢调节方面可能与脂肪组织有相似的作用。有研究证明在骨骼肌中表达的一些细胞因子确实可以调节脂肪代谢。本文综述了脂肪组织和骨骼肌信号之间的代谢关系。这两种组织的细胞因子在维持脂肪组织和骨骼肌足够比率方面有重要作用，因而在体重控制方面亦有重要作用。IL-15（在骨骼肌中高度表达）、TNF-α和瘦素在脂肪组织与骨骼肌之间联系中起着重要作用。
关键词： 脂质代谢；脂肪组织；骨骼肌；细胞因子

Lei Xiaoni^*

（  Physical Institute of Wuhan；  ）

Abstract： It has been demonstrated that adipose tissue plays a central role in energy homeostasis, behaving as an endocrine organ that expresses molecules involved in regulation of metabolism. Alterations in the expression or activity of those molecules have a fundamental role in pathologies such as obesity and insulin resistance. However, little is known about the role played by another tissue, skeletal muscle, which may have similar functions regarding metabolism control. Indeed, some molecules expressed in this tissue have recently been shown to modulate adipose metabolism. The present reviewconsiders the metabolic interrelationships and cross-talk of signals derived from both skeletal muscle and adipose tissue. It is suggested that cytokines derived from both tissues may have an important role in maintaining an adequate ratio of skeletal muscle to fat and thus may play an important role in the control of body weight. IL-15 (a cytokine highlyexpressed in skeletal muscle), TNF-a, and leptin could play a decisive role in the suggested ‘‘conversation’’ between adipose tissue and skeletal muscle. 
Keywords： lipid metabolism; adipose tissue; skeletal muscle; cytokines

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